Bringing the Entrepreneurial Mindset into Mining Engineering Education

There has been an ongoing debate on how to transform engineering education to better prepare students for today`s professional world that is characterized by increasingly complex problems and challenges that engineers are tasked with upon entering the industry. Within the conceive–design–implement–operate (CDIO) framework, entrepreneurship education presents a valuable pedagogical approach to foster the necessary skills of the students through integrated, hands-on, active learning experiences. While numerous publications have addressed possibilities of how experiential, problem-based, project-based and active learning can be integrated into engineering curriculum, there has been hardly any attention on mining engineering with respect to adopting this approach. This paper will address the possibilities of integrating entrepreneurship education into mining engineering programs in particular. This paper will enhance and foster discussion among academics from mining engineering on how to integrate elements of entrepreneurship education on a course, program and departmental level to infuse value creation experiences across the curriculum

Route 360, New Roads for Communication

The authors argue that engaging with narrative techniques in technological developments in film has implications for our senses and perceptions of realities that we can’t necessarily anticipate. But it should not restrain us from communicating by using new technology. We can’t control the museum visitors’ experiences, in spite of our guiding theories and methods, but we certainly have responsibility for setting issues in motion. Some of the multiple connections, conjunctions and layers we create by bringing our methods and technology to the narratives of an exhibition only become evident for us after the production of audiovisual material. These lead us to reflect in hindsight, hoping to raise our awareness about the implications in future projects. We discuss how newer technologies like 360 VR video can ‘rattle’ us out of our sensorial comfort zone because of the unexpected character of the viewing experience. And how does this affect our sense of reality in re-creating it audiovisually? We also explore the multiple significance of framing and montage in relation to the production of two films, based on participatory methods.Les auteurs soutiennent que l'utilisation des techniques narratives développées grâce à l'évolution technologique du cinéma a des répercussions sur nos sens et nos perceptions des réalités que nous ne pouvons pas nécessairement prévoir. Mais cette évolution ne doit pas nous empêcher de communiquer en utilisant ces nouveaux moyens technologiques. Malgré nos théories et méthodes, nous ne pouvons pas contrôler l'expérience des visiteurs du musée, mais nous avons certainement la responsabilité de permettre aux interactions d'exister. Certaines des multiples connexions, conjonctions et strates de lecture que nous créons grâce aux méthodes et aux technologies dédiées aux récits ne deviennent évidentes pour nous qu'après la production du matériel audiovisuel. Cela nous amène à réfléchir rétrospectivement, dans l'espoir de prendre conscience des implications en vue de projets futurs. Nous abordons d'une part la manière dont les nouvelles technologies comme la vidéo 360 VR peut nous faire sortir de notre zone de confort sensoriel en raison du caractère inattendu de l'expérience visuelle et d'autre part la manière dont cela affecte notre sens de la réalité en la recréant audiovisuellement? Nous explorons également les multiples significations du cadrage et du montage dans le cadre de la production de deux films qui s'appuient sur des méthodes participatives.Los autores argumentan que interactuar con las técnicas narrativas de los avances tecnológicos del cine tiene repercusiones para nuestros sentidos y nuestras percepciones de realidades que no siempre podemos prever. Sin embargo, eso no nos debería impedir comunicarnos mediante las nuevas tecnologías. No podemos controlar las experiencias de quienes visitan los museos, a pesar de las teorías y los métodos que nos orientan, pero sí tenemos la responsabilidad de poner los temas en movimiento. Algunas de las numerosas conexiones, combinaciones y capas que creamos al llevar nuestros métodos y nuestra tecnología a las narrativas de una exposición solo se nos hacen evidentes después de la producción del material audiovisual. Estas nos llevan a reflexionar en retrospectiva, con la esperanza de concienciarnos sobre las repercusiones en proyectos futuros. Analizamos cómo las tecnologías más modernas, como el vídeo 360 VR, pueden sacarnos de nuestra zona de confort sensorial dado el carácter inesperado de la experiencia de visionado. ¿Y cómo afecta eso a nuestro sentido de la realidad al recrearla audiovisualmente? También exploramos la diferente trascendencia del encuadre y el montaje en relación con la producción de dos documentales basada en métodos participativos

Aleutian Mink Disease Virus and Humans

Reports of a possible relationship between Aleutian mink disease parvovirus (AMDV) and human infection are rare. However, 2 mink farmers with vascular disease and microangiopathy similar to that in mink with Aleutian disease were found to have AMDV-specific antibodies and AMDV DNA. These findings raise the suspicion that AMDV may play a role in human disease

Altered regulation and expression of genes by BET family of proteins in COPD patients

Correction: PLoS One 2018 12 (4): 0175997Background BET proteins (BRD2, BRD3, BRDT and BRD4) belong to the family of bromodomain containing proteins, which form a class of transcriptional co-regulators. BET proteins bind to acetylated lysine residues in the histones of nucleosomal chromatin and function either as co-activators or co-repressors of gene expression. An imbalance between HAT and HDAC activities resulting in hyperacetylation of histones has been identified in COPD. We hypothesized that pan-BET inhibitor (JQ1) treatment of BET protein interactions with hyperacety-lated sites in the chromatin will regulate excessive activation of pro-inflammatory genes in key inflammatory drivers of alveolar macrophages (AM) in COPD. Methods and findings Transcriptome analysis of AM from COPD patients indicated up-regulation of macrophage M1 type genes upon LPS stimulation. Pan-BET inhibitor JQ1 treatment attenuated expression of multiple genes, including pro-inflammatory cytokines and regulators of innate and adaptive immune cells. We demonstrated for the first time that JQ1 differentially modulated LPS-induced cytokine release from AM or peripheral blood mononuclear cells (PBMC) of COPD patients compared to PBMC of healthy controls. Using the BET regulated gene signature, we identified a subset of COPD patients, which we propose to benefit from BET inhibition. Conclusions This work demonstrates that the effects of pan-BET inhibition through JQ1 treatment of inflammatory cells differs between COPD patients and healthy controls, and the expression of BET protein regulated genes is altered in COPD. These findings provide evidence of histone hyperacetylation as a mechanism driving chronic inflammatory changes in COPD.Peer reviewe

Induced pluripotent stem cells (iPSCs) derived from af pre-symptomatic carrier of a R406W mutation in microtubule-associated protein tau (MAPT) causing frontotemporal dementia

AbstractSkin fibroblasts were obtained from a 28-year-old pre-symptomatic woman carrying a R406W mutation in microtubule-associated protein tau (MAPT), known to cause frontotemporal dementia. Induced pluripotent stem cell (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.1216C>T substitution in exon 13 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro

Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a P301L mutation in microtubule-associated protein tau (MAPT)

AbstractSkin fibroblasts were obtained from a 57-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a P301L mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.902C>T substitution in exon 10 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro

Differential adipokine DNA methylation and gene expression in subcutaneous adipose tissue from adult offspring of women with diabetes in pregnancy

Abstract Background Offspring of women with diabetes in pregnancy are at increased risk of type 2 diabetes mellitus (T2DM), potentially mediated by epigenetic mechanisms. The adipokines leptin, adiponectin, and resistin (genes: LEP, ADIPOQ, RETN) play key roles in the pathophysiology of T2DM. We hypothesized that offspring exposed to maternal diabetes exhibit alterations in epigenetic regulation of subcutaneous adipose tissue (SAT) adipokine transcription. We studied adipokine plasma levels, SAT gene expression, and DNA methylation of LEP, ADIPOQ, and RETN in adult offspring of women with gestational diabetes (O-GDM, N = 82) or type 1 diabetes (O-T1DM, N = 67) in pregnancy, compared to offspring of women from the background population (O-BP, N = 57). Results Compared to O-BP, we found elevated plasma leptin and resistin levels in O-T1DM, decreased gene expression of all adipokines in O-GDM, decreased RETN expression in O-T1DM, and increased LEP and ADIPOQ methylation in O-GDM. In multivariate regression analysis, O-GDM remained associated with increased ADIPOQ methylation and decreased ADIPOQ and RETN gene expression and O-T1DM remained associated with decreased RETN expression after adjustment for potential confounders and mediators. Conclusions In conclusion, offspring of women with diabetes in pregnancy exhibit increased ADIPOQ DNA methylation and decreased ADIPOQ and RETN gene expression in SAT. However, altered methylation and expression levels were not reflected in plasma protein levels, and the functional implications of these findings remain uncertain

Assessment of Attention Deficits in Adolescent Offspring Exposed to Maternal Type 1 Diabetes

The aim of this study was to examine the potential association between intrauterine exposure to maternal diabetes and attention deficits in the offspring.Adolescent offspring of a prospectively followed cohort of women with type 1 diabetes (n = 269) and a control group from the background population (n = 293) participated in a follow-up assessment in 2012-2013. We used scores from Conners Continuous Performance Test II to assess attention and based on a principal component analysis we evaluated scores on five different attention factors: focused attention, vigilance, hyperactivity/impulsivity, sustained attention and response style.A higher frequency of the exposed offspring had a parent/self-reported use of Attention Deficit Hyperactivity Disorder (ADHD) medication compared to the control group (2.2% vs. 0.0%, p = 0.01). Clinical significant differences between adolescents exposed to maternal diabetes and unexposed controls were not found in either single scores on Conners Continuous Performance Test or on any of the five attention factors identified.Exposure to maternal type 1 diabetes did not seem to increase the risk of attention deficits in the adolescent offspring. However, a higher self-reported use of ADHD medication in the exposed group could suggest a difference in attention not revealed by the applied test